Movement and force produced by a single myosin head

@article{Molloy1995MovementAF,
  title={Movement and force produced by a single myosin head},
  author={J. Molloy and J. Burns and J. Kendrick-Jones and R. Tregear and D. White},
  journal={Nature},
  year={1995},
  volume={378},
  pages={209-212}
}
  • J. Molloy, J. Burns, +2 authors D. White
  • Published 1995
  • Medicine, Chemistry
  • Nature
  • MUSCLE contraction is driven by the cyclical interaction of myosin with actin, coupled to the breakdown of ATP. Studies of the interaction of filamentous myosin1 and of a double-headed proteolytic fragment, heavy meromyosin (HMM)2,3, with actin have demonstrated discrete mechanical events, arising from stochastic interaction of single myosin molecules with actin. Here we show, using an optical-tweezers transducer2,4, that a single myosin subfragment-1 (S1), which is a single myosin head, can… CONTINUE READING

    Topics from this paper.

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 359 CITATIONS, ESTIMATED 55% COVERAGE

    Visualizing myosin's power stroke in muscle contraction.

    • M. Reedy
    • Chemistry, Biology, Medicine
    • Journal of cell science
    • 2000
    VIEW 1 EXCERPT

    A mutant heterodimeric myosin with one inactive head generates maximal displacement

    VIEW 3 EXCERPTS
    CITES RESULTS & BACKGROUND

    FILTER CITATIONS BY YEAR

    1996
    2020

    CITATION STATISTICS

    • 17 Highly Influenced Citations

    • Averaged 13 Citations per year from 2018 through 2020