Movement and force produced by a single myosin head

@article{Molloy1995MovementAF,
  title={Movement and force produced by a single myosin head},
  author={Justin E. Molloy and Julie E. Burns and John Kendrick‐Jones and Richard T. Tregear and David C. S. White},
  journal={Nature},
  year={1995},
  volume={378},
  pages={209-212}
}
MUSCLE contraction is driven by the cyclical interaction of myosin with actin, coupled to the breakdown of ATP. Studies of the interaction of filamentous myosin1 and of a double-headed proteolytic fragment, heavy meromyosin (HMM)2,3, with actin have demonstrated discrete mechanical events, arising from stochastic interaction of single myosin molecules with actin. Here we show, using an optical-tweezers transducer2,4, that a single myosin subfragment-1 (S1), which is a single myosin head, can… 
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