• DOI:10.1038/378209a0
Corpus ID: 4334476

Movement and force produced by a single myosin head

@article{Molloy1995MovementAF,
  title={Movement and force produced by a single myosin head},
  author={J. Molloy and J. Burns and J. Kendrick-Jones and R. Tregear and D. White},
  journal={Nature},
  year={1995},
  volume={378},
  pages={209-212}
}

J. Molloy, J. Burns, +2 authors D. White

Published 1995

Medicine, Chemistry

Nature

MUSCLE contraction is driven by the cyclical interaction of myosin with actin, coupled to the breakdown of ATP. Studies of the interaction of filamentous myosin1 and of a double-headed proteolytic fragment, heavy meromyosin (HMM)2,3, with actin have demonstrated discrete mechanical events, arising from stochastic interaction of single myosin molecules with actin. Here we show, using an optical-tweezers transducer2,4, that a single myosin subfragment-1 (S1), which is a single myosin head, can… CONTINUE READING

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