Move it or lose it: axis specification in Xenopus.

@article{Weaver2004MoveIO,
  title={Move it or lose it: axis specification in Xenopus.},
  author={Carole Weaver and David Kimelman},
  journal={Development},
  year={2004},
  volume={131 15},
  pages={3491-9}
}
A long-standing question in developmental biology is how amphibians establish a dorsoventral axis. The prevailing view has been that cortical rotation is used to move a dorsalizing activity from the bottom of the egg towards the future dorsal side. We review recent evidence that kinesin-dependent movement of particles containing components of the Wnt intracellular pathway contributes to the formation of the dorsal organizer, and suggest that cortical rotation functions to align and orient… CONTINUE READING
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