Mouse zeta- and alpha-globin genes: embryonic survival, alpha-thalassemia, and genetic background effects.


A classical notion regarding the expression of murine embryonic zeta- and adult alpha-globin genes holds that there is a switch in globin production from the embryonic to the adult form during fetal development. Our previous in situ hybridization studies challenged this view, since both zeta- and alpha-globin mRNAs can be detected simultaneously in the… (More)


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