Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel.

@article{Vannier1999MouseTT,
  title={Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel.},
  author={B Vannier and Michael Peyton and Guylain Boulay and Darren M Brown and Ning Qin and Minshan Jiang and Xi Zhu and Lutz Birnbaumer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 5},
  pages={2060-4}
}
Capacitative Ca2+ entry (CCE) is Ca2+ entering after stimulation of inositol 1,4,5-trisphosphate (IP3) formation and initiation of Ca2+ store depletion. One hallmark of CCE is that it can also be triggered merely by store depletion, as occurs after inhibition of internal Ca2+ pumps with thapsigargin. Evidence has accumulated in support of a role of transient receptor potential (Trp) proteins as structural subunits of a class of Ca2+-permeable cation channels activated by agonists that stimulate… CONTINUE READING

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