Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics

@inproceedings{Cole2014MouseTA,
  title={Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics},
  author={Francesca Cole and Fr{\'e}d{\'e}ric Baudat and Corinne Grey and Scott Keeney and Bernard de Massy and Maria Jasin},
  booktitle={Nature Genetics},
  year={2014}
}
The ability to examine all chromatids from a single meiosis in yeast tetrads has been indispensable for defining the mechanisms of homologous recombination initiated by DNA double-strand breaks (DSBs). Using a broadly applicable strategy for the analysis of chromatids from a single meiosis at two recombination hotspots in mouse oocytes and spermatocytes, we demonstrate here the unidirectional transfer of information—gene conversion—in both crossovers and noncrossovers. Whereas gene conversion… CONTINUE READING
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