Mouse strain-dependent differences in susceptibility to Neisseria gonorrhoeae infection and induction of innate immune responses.

@article{Packiam2010MouseSD,
  title={Mouse strain-dependent differences in susceptibility to Neisseria gonorrhoeae infection and induction of innate immune responses.},
  author={Mathanraj Packiam and Sandra J. Veit and Deborah Jean Anderson and Robin R. Ingalls and Ann E Jerse},
  journal={Infection and immunity},
  year={2010},
  volume={78 1},
  pages={
          433-40
        }
}
Acute gonorrhea in women is characterized by a mucopurulent exudate that contains polymorphonuclear leukocytes (PMNs) with intracellular gonococci. Asymptomatic infections are also common. Information on the innate response to Neisseria gonorrhoeae in women is limited to studies with cultured cells, isolated immune cells, and analyses of cervicovaginal fluids. 17beta-Estradiol-treated BALB/c mice can be experimentally infected with N. gonorrhoeae, and a vaginal PMN influx occurs in 50 to 80% of… CONTINUE READING

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