Mouse strain-dependent caspase activation during acetaminophen hepatotoxicity does not result in apoptosis or modulation of inflammation.

Abstract

UNLABELLED The mechanisms of acetaminophen (APAP)-mediated hepatic oncotic necrosis have been extensively characterized. However, it was recently demonstrated that fed CD-1 mice have a transient caspase activation which initiates apoptosis. To evaluate these findings in more detail, outbred (Swiss Webster, SW) and inbred (C57BL/6) mice were treated with… (More)
DOI: 10.1016/j.taap.2011.10.006

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Cite this paper

@article{Williams2011MouseSC, title={Mouse strain-dependent caspase activation during acetaminophen hepatotoxicity does not result in apoptosis or modulation of inflammation.}, author={Clarence David Williams and Michael Koerner and Jed N. Lampe and Anwar I Farhood and Hartmut Jaeschke}, journal={Toxicology and applied pharmacology}, year={2011}, volume={257 3}, pages={449-58} }