Mouse stem cells seeded into decellularized rat kidney scaffolds endothelialize and remodel basement membranes.

@article{Ross2012MouseSC,
  title={Mouse stem cells seeded into decellularized rat kidney scaffolds endothelialize and remodel basement membranes.},
  author={Edward Allen Ross and Dale R. Abrahamson and Patricia L. St. John and William L. Clapp and Matthew James Williams and Naohiro Terada and Takashi Hamazaki and Gary W. Ellison and Christopher D. Batich},
  journal={Organogenesis},
  year={2012},
  volume={8 2},
  pages={49-55}
}
INTRODUCTION To address transplant organ shortage, a promising strategy is to decellularize kidneys in a manner that the scaffold retains signals for seeded pluripotent precursor cells to differentiate and recapitulate native structures: matrix-to-cell signaling followed by cell-cell and cell-matrix interactions, thereby remodeling and replacing the original matrix. This would reduce scaffold antigenicity and enable xeno-allografts. RESULTS DAPI-labeled cells in arterial vessels and glomeruli… CONTINUE READING

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