Mouse skin is particularly susceptible to tumor initiation during early anagen of the hair cycle: possible involvement of hair follicle stem cells.

@article{Miller1993MouseSI,
  title={Mouse skin is particularly susceptible to tumor initiation during early anagen of the hair cycle: possible involvement of hair follicle stem cells.},
  author={Stanley J. Miller and Zhengyu Wei and Colleen L Wilson and Leonard M Dzubow and Tim Thomas Sun and Robert M Lavker},
  journal={The Journal of investigative dermatology},
  year={1993},
  volume={101 4},
  pages={591-4}
}
Stem cells are believed to be a necessary target of chemical carcinogens. Based on autoradiographic, ultrastructural, and biologic criteria, we have recently proposed that hair follicle stem cells reside not in the bulb, but in the upper outer root sheath in an area called the bulge. Proliferating cells have been shown to be more susceptible to tumor initiation, and we have recently demonstrated that cells in the bulge undergo transient proliferation during early anagen. Therefore, we theorized… CONTINUE READING

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