Mouse running activity is lowered by Brucella abortus treatment: a potential model to study chronic fatigue.

@article{Ottenweller1998MouseRA,
  title={Mouse running activity is lowered by Brucella abortus treatment: a potential model to study chronic fatigue.},
  author={John E. Ottenweller and Benjamin H. Natelson and William C. Gause and Kenneth K. Carroll and Dawn Beldowicz and Xue Dong Zhou and John J Lamanca},
  journal={Physiology & behavior},
  year={1998},
  volume={63 5},
  pages={795-801}
}
Chronic fatigue syndrome, which can occur after acute infection and last for years, is characterized by severe and persistent fatigue. Others have reported decreases in mouse running activity following infection and have suggested this may provide an animal model for studying chronic fatigue. Voluntary running is a highly motivated activity in mice, which will often run 5-7 mi/day in our laboratory. Following 2 weeks of acclimation to running wheels with food and water available ad lib, female… CONTINUE READING

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