Mouse pharmacokinetics and metabolism of the curcumin analog, 4-piperidinone,3,5-bis[(2-fluorophenyl)methylene]-acetate(3E,5E) (EF-24; NSC 716993)

@article{Reid2014MousePA,
  title={Mouse pharmacokinetics and metabolism of the curcumin analog, 4-piperidinone,3,5-bis[(2-fluorophenyl)methylene]-acetate(3E,5E) (EF-24; NSC 716993)},
  author={J. Macnair Reid and Sarah A. Buhrow and Jeremiah A. Gilbert and Lee Jia and Mamoru Sakai-shi Shoji and James P. Snyder and Matthew Ames},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2014},
  volume={73},
  pages={1137-1146}
}
Curcumin, a keto-enol constituent of turmeric, has in vitro and in vivo antitumor activity. However, in vivo potency is low due to poor oral absorption. The mono-carbonyl analog, 3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone acetate (EF-24, NSC 716993), exhibited broad-spectrum activity in the NCI anticancer cell line screen and potent antiangiogenesis activity in a HUVEC cell migration assay. The purpose of this study was to characterize the preclinical pharmacology of EF-24 in mice. EF-24… CONTINUE READING
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References

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SHOWING 1-10 OF 31 REFERENCES

Inhibition of the nFkB signaling pathway by the curcumin analog , 3 , 5bis ( 2pyridinylmethylidene )4 piperidone ( eF 31 ) : anti - inflammatory and anti - cancer properties

  • Olivera a, Moore tW, +6 authors Pace tW
  • Int Immunopharmacol
  • 2010

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