Mouse otocyst transuterine gene transfer restores hearing in mice with connexin 30 deletion-associated hearing loss.

@article{Miwa2013MouseOT,
  title={Mouse otocyst transuterine gene transfer restores hearing in mice with connexin 30 deletion-associated hearing loss.},
  author={Toru Miwa and Ryosei Minoda and Momoko Ise and Takao Yamada and Eiji Yumoto},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2013},
  volume={21 6},
  pages={1142-50}
}
Although numerous causative genes for hereditary hearing loss have been identified, there are no fundamental treatments for this condition. Herein, we describe a novel potential treatment for genetic hearing loss. Because mutations or deletions in the connexin (Cx) genes are common causes of profound congenital hearing loss in both humans and mice, we investigated whether gene supplementation therapy using the wild-type Cx gene could cure hearing loss. We first generated inner ear-specific… CONTINUE READING