Mouse neutrophils are professional antigen-presenting cells programmed to instruct Th1 and Th17 T-cell differentiation.

@article{Abdallah2011MouseNA,
  title={Mouse neutrophils are professional antigen-presenting cells programmed to instruct Th1 and Th17 T-cell differentiation.},
  author={Delbert S. Abi Abdallah and Charlotte E. Egan and Barbara A. Butcher and Eric Y. Denkers},
  journal={International immunology},
  year={2011},
  volume={23 5},
  pages={
          317-26
        }
}
Neutrophils play a major role in the innate immune system and are normally considered to be short-lived effector cells that exert anti-microbial activity and sometimes immunopathology. Here, we show that these cells possess an additional function as professional antigen-presenting cells capable of priming a T(h)1- and T(h)17-acquired immune response. Using flow cytometry, fluorescence microscopy and western blotting, we show that mouse neutrophils express MHC class II and co-stimulatory… CONTINUE READING
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