Mouse models of thrombosis: thrombomodulin.

  title={Mouse models of thrombosis: thrombomodulin.},
  author={H. Weiler},
  journal={Thrombosis and haemostasis},
  volume={92 3},
  • H. Weiler
  • Published 2004 in Thrombosis and haemostasis
This review describes animal models of TM-deficiency that cause thrombosis in mice. Thrombomodulin (TM) is a key component of the protein C anticoagulant pathway by facilitating the activation of protein C by thrombin. In addition, TM integrates fibrinolytic and anti-inflammatory responses in a manner that is in part independent of protein C and thrombin. A series of genetically modified mouse strains is available in which the various and distinct functions of TM have been altered by means of… CONTINUE READING