Mouse models of neural tube defects: investigating preventive mechanisms.

@article{Greene2005MouseMO,
  title={Mouse models of neural tube defects: investigating preventive mechanisms.},
  author={Nicholas D. E. Greene and Andrew J Copp},
  journal={American journal of medical genetics. Part C, Seminars in medical genetics},
  year={2005},
  volume={135C 1},
  pages={31-41}
}
Neural tube defects (NTD), including anencephaly and spina bifida, are a group of severe congenital abnormalities in which the future brain and/or spinal cord fail to close. In mice, NTD may result from genetic mutations or knockouts, or from exposure to teratogenic agents, several of which are known risk factors in humans. Among the many mouse NTD models that have been identified to date, a number have been tested for possible primary prevention of NTD by exogenous agents, such as folic acid… CONTINUE READING