Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease.

@article{Machado2015MouseMO,
  title={Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease.},
  author={Mariana Verdelho Machado and Gregory Alexander Michelotti and Guanhua Xie and Thiago de Almeida Pereira and J Boursier and Brittany Bohnic and Cynthia D. Guy and Anna Mae Diehl},
  journal={PloS one},
  year={2015},
  volume={10 5},
  pages={e0127991}
}
BACKGROUND AND AIMS Non-alcoholic steatohepatitis (NASH), the potentially progressive form of nonalcoholic fatty liver disease (NAFLD), is the pandemic liver disease of our time. Although there are several animal models of NASH, consensus regarding the optimal model is lacking. We aimed to compare features of NASH in the two most widely-used mouse models: methionine-choline deficient (MCD) diet and Western diet. METHODS Mice were fed standard chow, MCD diet for 8 weeks, or Western diet (45… CONTINUE READING

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