Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studies.

@article{Tschida2014MouseMO,
  title={Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studies.},
  author={Barbara R. Tschida and David A. Largaespada and Vincent W Keng},
  journal={Seminars in cell & developmental biology},
  year={2014},
  volume={27},
  pages={86-95}
}
The genetic complexity and heterogeneity of cancer has posed a problem in designing rationally targeted therapies effective in a large proportion of human cancer. Genomic characterization of many cancer types has provided a staggering amount of data that needs to be interpreted to further our understanding of this disease. Forward genetic screening in mice using Sleeping Beauty (SB) based insertional mutagenesis is an effective method for candidate cancer gene discovery that can aid in… CONTINUE READING
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