Mouse models of Rett syndrome: from behavioural phenotyping to preclinical evaluation of new therapeutic approaches

  title={Mouse models of Rett syndrome: from behavioural phenotyping to preclinical evaluation of new therapeutic approaches},
  author={L. Ricceri and B. De Filippis and G. Laviola},
  journal={Behavioural Pharmacology},
  • L. Ricceri, B. De Filippis, G. Laviola
  • Published 2008
  • Medicine
  • Behavioural Pharmacology
  • Rett syndrome (RTT) is a neurodevelopmental disorder, primarily affecting girls. RTT causes severe cognitive, social, motor and physiological impairments and no cure currently exists. The discovery of a monogenic origin for RTT and the subsequent generation of RTT mouse models provided a major breakthrough for RTT research. Although the characterization of these mutant mice is far from complete, they recapitulate several RTT symptoms. This review provides an overview of the behavioural domains… CONTINUE READING
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