Mouse models of ALS: Past, present and future

  title={Mouse models of ALS: Past, present and future},
  author={C. Lutz},
  journal={Brain Research},
  • C. Lutz
  • Published 2018
  • Biology, Medicine
  • Brain Research
  • Genome sequencing of both sporadic and familial patients of Amyotrophic Lateral Sclerosis (ALS) has led to the identification of new genes that are both contributing and causative in the disease. This gene discovery has come at an unprecedented rate, and much of it in recent years. Knowledge of these genetic mutations provides us with opportunities to uncover new and related mechanisms, increasing our understanding of the disease and bringing us closer to defined therapies for patients. Mouse… CONTINUE READING
    33 Citations

    Topics from this paper.

    P2X7 Receptor Antagonism as a Potential Therapy in Amyotrophic Lateral Sclerosis
    • 1
    • PDF
    Animal models of neurodegenerative diseases
    • 58
    Glial Cells—The Strategic Targets in Amyotrophic Lateral Sclerosis Treatment
    • 6
    • PDF
    RNA processing dysfunction in TDP-ALS
    Dysregulation of RNA-Binding Proteins in Amyotrophic Lateral Sclerosis
    • 5
    • PDF


    Pathogenesis of FUS-associated ALS and FTD: insights from rodent models
    • 52
    Design, power, and interpretation of studies in the standard murine model of ALS
    • S. Scott, J. E. Kranz, +9 authors J. Heywood
    • Medicine
    • Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
    • 2008
    • 432
    • PDF
    NEK1 mutations in familial amyotrophic lateral sclerosis.
    • 71
    • PDF
    NEK1 variants confer susceptibility to amyotrophic lateral sclerosis
    • 127
    • PDF