Mouse models for studying prostate cancer bone metastasis.

Abstract

Once tumor cells metastasize to the bone, the prognosis for prostate cancer patients is generally very poor. The mechanisms involved in bone metastasis, however, remain elusive, because of lack of relevant animal models. In this manuscript, we describe step-by-step protocols for the xenograft mouse models that are currently used for studying prostate cancer bone metastasis. The different routes of tumor inoculation (intraosseous, intracardiac, intravenous and orthotopic) presented are useful for exploring the biology of bone metastasis.

DOI: 10.1038/bonekey.2016.4

Cite this paper

@article{Dai2016MouseMF, title={Mouse models for studying prostate cancer bone metastasis.}, author={Jinlu Dai and Janine Hensel and Ning Wang and Marianna Kruithof-de Julio and Yusuke Shiozawa}, journal={BoneKEy reports}, year={2016}, volume={5}, pages={777} }