Mouse models for preeclampsia: disruption of redox-regulated signaling

@article{Banerjee2009MouseMF,
  title={Mouse models for preeclampsia: disruption of redox-regulated signaling},
  author={Subhasis Banerjee and Harpal Randeva and Anne Elizabeth Chambers},
  journal={Reproductive Biology and Endocrinology : RB&E},
  year={2009},
  volume={7},
  pages={4 - 4}
}
The concept that oxidative stress contributes to the development of human preeclampsia has never been tested in genetically-defined animal models. Homozygous deletion of catechol-O-methyl transferase (Comt-/-) in pregnant mice leads to human preeclampsia-like symptoms (high blood pressure, albuminurea and preterm birth) resulting from extensive vasculo-endothelial pathology, primarily at the utero-fetal interface where maternal cardiac output is dramatically increased during pregnancy. Comt… CONTINUE READING
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, proteinuria , and poor feto - placental outcomes in BPH / 5 mouse model of preeclampsia

  • K Kanasaki, K Palmsten, +9 authors R Kalluri
  • 2008

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