Mouse models as tools for dissecting disorders of lipoprotein metabolism.

@article{Marschang2003MouseMA,
  title={Mouse models as tools for dissecting disorders of lipoprotein metabolism.},
  author={Peter Marschang and Joachim Herz},
  journal={Seminars in cell & developmental biology},
  year={2003},
  volume={14 1},
  pages={25-35}
}
The overexpression of proteins as transgenes or by adenovirus-mediated gene transfer as well as the disruption of genes by homologous DNA recombination in the mouse provide powerful tools to dissect the role of individual proteins in complex biological pathways. These and similar techniques have been widely used to characterize the function of most of the… CONTINUE READING