Mouse model of subretinal neovascularization with choroidal anastomosis.

  title={Mouse model of subretinal neovascularization with choroidal anastomosis.},
  author={John R. Heckenlively and Norman L. Hawes and Martin Friedlander and Steven Nusinowitz and Ronald E. Hurd and Muriel T. Davisson and B. -Y. Chang},
  volume={23 4},
PURPOSE To characterize the phenotype and report a reliable genetic model of retinal angiogenesis and subretinal neovascularization in the mouse. METHODS The mouse phenotype was characterized using ophthalmoscopy, fundus photography, fluorescein angiography, electroretinography, histology, gene sequencing, and linkage analysis. RESULTS Scattered pink-gray retinal lesions were found on ophthalmoscopy and were confirmed to be subretinal neovascularization on fluorescein angiography. On… CONTINUE READING