Mouse model of focal cerebral ischemia using endothelin-1.

  title={Mouse model of focal cerebral ischemia using endothelin-1.},
  author={Nobutaka Horie and Anne-Lise D. Maag and Scott A. Hamilton and Hideo Shichinohe and Tonya M. Bliss and G K Steinberg},
  journal={Journal of neuroscience methods},
  volume={173 2},
Intracerebral injection of the vasoconstrictor peptide, endothelin-1 (ET-1), has been used as a method to induce focal ischemia in rats. The relative technical simplicity of this model makes it attractive for use in mice. However, the effect of ET-1 on mouse brains has not been firmly established. In this study, we determined the ability of ET-1 to induce focal cerebral ischemia in four different mouse strains (CD1, C57/BL6, NOD/SCID, and FVB). In contrast to rats, intracerebral injection of ET… CONTINUE READING