Mouse model of arterial injury.

@article{Lindner1993MouseMO,
  title={Mouse model of arterial injury.},
  author={V. Lindner and J. Fingerle and M. Reidy},
  journal={Circulation research},
  year={1993},
  volume={73 5},
  pages={
          792-6
        }
}
  • V. Lindner, J. Fingerle, M. Reidy
  • Published 1993
  • Biology, Medicine
  • Circulation research
  • In the present study, we established an injury model of the mouse carotid artery. Complete removal of the endothelium was achieved with a flexible wire. A platelet monolayer covered the denuded surface, and damage to underlying medial smooth muscle cells (SMCs) was detected. Injection of [3H]thymidine was used to determine the replication index for medial SMCs, which was found to be 1.6% at 2 days after denudation and 9.8% at 5 days. SMCs were observed in the intima by day 8 (replication index… CONTINUE READING
    374 Citations

    Figures and Topics from this paper.

    Remodeling with neointima formation in the mouse carotid artery after cessation of blood flow.
    • 368
    Endoluminal arterial injury in plasminogen-deficient mice.
    • 19

    References

    SHOWING 1-10 OF 16 REFERENCES
    Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium.
    • 1,523
    Endothelial regeneration. V. Inhibition of endothelial regrowth in arteries of rat and rabbit.
    • 177
    Role of basic fibroblast growth factor in vascular lesion formation.
    • 519
    • PDF
    Proliferation of smooth muscle cells after vascular injury is inhibited by an antibody against basic fibroblast growth factor.
    • V. Lindner, M. Reidy
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1991
    • 716
    • PDF