Mouse model of arterial injury.

  title={Mouse model of arterial injury.},
  author={Volkhard Lindner and J{\"u}rgen Fingerle and Michael A. Reidy},
  journal={Circulation research},
  volume={73 5},
In the present study, we established an injury model of the mouse carotid artery. Complete removal of the endothelium was achieved with a flexible wire. A platelet monolayer covered the denuded surface, and damage to underlying medial smooth muscle cells (SMCs) was detected. Injection of [3H]thymidine was used to determine the replication index for medial SMCs, which was found to be 1.6% at 2 days after denudation and 9.8% at 5 days. SMCs were observed in the intima by day 8 (replication index… CONTINUE READING

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Antisense cmyb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo

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