Mouse model of arterial injury.

  title={Mouse model of arterial injury.},
  author={V. Lindner and J. Fingerle and M. Reidy},
  journal={Circulation research},
  volume={73 5},
  • V. Lindner, J. Fingerle, M. Reidy
  • Published 1993
  • Biology, Medicine
  • Circulation research
  • In the present study, we established an injury model of the mouse carotid artery. Complete removal of the endothelium was achieved with a flexible wire. A platelet monolayer covered the denuded surface, and damage to underlying medial smooth muscle cells (SMCs) was detected. Injection of [3H]thymidine was used to determine the replication index for medial SMCs, which was found to be 1.6% at 2 days after denudation and 9.8% at 5 days. SMCs were observed in the intima by day 8 (replication index… CONTINUE READING
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    • V. Lindner, M. Reidy
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1991
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