Mouse model of OPRM1 (A118G) polymorphism increases sociability and dominance and confers resilience to social defeat.

@article{Briand2015MouseMO,
  title={Mouse model of OPRM1 (A118G) polymorphism increases sociability and dominance and confers resilience to social defeat.},
  author={Lisa A Briand and Monica R. F. Hil{\'a}rio and Holly C Dow and Edward S. Brodkin and Julie A. Blendy and Olivier Berton},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2015},
  volume={35 8},
  pages={3582-90}
}
A single nucleotide polymorphism (SNP) in the human μ-opioid receptor gene (OPRM1 A118G) has been widely studied for its association in drug addiction, pain sensitivity, and, more recently, social behavior. The endogenous opioid system has been shown to regulate social distress and reward in a variety of animal models. However, mechanisms underlying the associations between the OPRM1 A118G SNP and these behaviors have not been clarified. We used a mouse model possessing the human equivalent… CONTINUE READING
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