Mouse model mimics multiple sclerosis in the clinico-radiological paradox.

  title={Mouse model mimics multiple sclerosis in the clinico-radiological paradox.},
  author={Jens Wuerfel and Eva Tysiak and Timour Prozorovski and Maureen Smyth and Susanne Mueller and J{\"o}rg Schnorr and Matthias Taupitz and Frauke Zipp},
  journal={The European journal of neuroscience},
  volume={26 1},
The value of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, in deriving novel diagnostic and therapeutic input has been subject to recent debate. This study is the first to report a disseminated distribution of plaques including cranial nerves, prior to or at early stages of disease in murine adoptive transfer EAE, irrespective of the development of clinical symptoms. We induced EAE by adoptive proteolipid protein-specific T-cell transfer in 26 female… CONTINUE READING


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