Mouse mammary tumor virus gene expression is suppressed by oligomeric ellagitannins, novel inhibitors of poly(ADP-ribose) glycohydrolase.

@article{Tsai1992MouseMT,
  title={Mouse mammary tumor virus gene expression is suppressed by oligomeric ellagitannins, novel inhibitors of poly(ADP-ribose) glycohydrolase.},
  author={Y J Tsai and Tsutomu Aoki and Hiroshi Maruta and Hideharu Abe and Hideki Sakagami and Tsutomu Hatano and Tomohiko Okuda and Sei-ich Tanuma},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 20},
  pages={14436-42}
}
Oligomeric ellagitannins (nobotanins B, E, and K) were found to be potent inhibitors of poly(ADP-ribose) glycohydrolase purified from mouse mammary tumor 34I cells. Kinetic analysis revealed that the inhibition of nobotanin B (dimer) was competitive with respect to the substrate poly(ADP-ribose), whereas nobotanin E (trimer) and nobotanin K (tetramer) exhibited mixed-type inhibition. These results suggest that the dimeric structure of ellagitannin may have a functional domain that competes with… CONTINUE READING
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