Mouse mammary tumor virus c-rel transgenic mice develop mammary tumors.

  title={Mouse mammary tumor virus c-rel transgenic mice develop mammary tumors.},
  author={Rapha{\"e}lle Romieu-Mourez and Dong Sung Kim and Sang Min Shin and Elizabeth G Demicco and Esther Landesman-Bollag and David C. Seldin and Robert Cardiff and Gail E. Sonenshein},
  journal={Molecular and cellular biology},
  volume={23 16},
Amplification, overexpression, or rearrangement of the c-rel gene, encoding the c-Rel NF-kappaB subunit, has been reported in solid and hematopoietic malignancies. For example, many primary human breast cancer tissue samples express high levels of nuclear c-Rel. While the Rev-T oncogene v-rel causes tumors in birds, the ability of c-Rel to transform in vivo has not been demonstrated. To directly test the role of c-Rel in breast tumorigenesis, mice were generated in which overexpression of mouse… CONTINUE READING


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Differential regulation of the c-myc oncogene promoter by the NF- B rel family of transcription factors

  • F. A. La Rosa, J. W. Pierce, G. E. Sonenshein
  • 1994
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