Mouse mammary carcinoma cell line (BALB/c-MC) stimulates osteoclast formation from mouse bone marrow cells through cell-to-cell contact.

@article{Ono1998MouseMC,
  title={Mouse mammary carcinoma cell line (BALB/c-MC) stimulates osteoclast formation from mouse bone marrow cells through cell-to-cell contact.},
  author={Katsuhiro Ono and Takuhiko Akatsu and Takehiko Murakami and Seiki Wada and Mitsuo Nishikawa and Nobuo Kugai and Michiko Yamamoto and Nami Matsuura and Naokazu Nagata},
  journal={Bone},
  year={1998},
  volume={23 1},
  pages={27-32}
}
We recently reported that numerous osteoclasts (OC) were formed in cocultures of some mouse cancer cell lines and bone marrow cells. In this study, we examined mechanisms by which one of the cell lines, BALB/c-MC, induces OC. BALB/c-MC dose dependently stimulated OC formation in cocultures. In cocultures where direct cell-to-cell contact between BALB/c-MC and bone marrow cells was inhibited by membrane filters, OC formation was not stimulated. The stimulation of OC formation in the coculture… CONTINUE READING
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