Mouse low-grade gliomas contain cancer stem cells with unique molecular and functional properties.

@article{Chen2015MouseLG,
  title={Mouse low-grade gliomas contain cancer stem cells with unique molecular and functional properties.},
  author={Y Chen and Lucy D'Agostino McGowan and Patrick J Cimino and Sonika Dahiya and Jeffrey Russell Leonard and Da Yong Lee and David H Gutmann},
  journal={Cell reports},
  year={2015},
  volume={10 11},
  pages={1899-912}
}
The availability of adult malignant glioma stem cells (GSCs) has provided unprecedented opportunities to identify the mechanisms underlying treatment resistance. Unfortunately, there is a lack of comparable reagents for the study of pediatric low-grade glioma (LGG). Leveraging a neurofibromatosis 1 (Nf1) genetically engineered mouse LGG model, we report the isolation of CD133(+) multi-potent low-grade glioma stem cells (LG-GSCs), which generate glioma-like lesions histologically similar to the… CONTINUE READING
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