Mouse liver repopulation with hepatocytes generated from human fibroblasts

@inproceedings{Zhu2014MouseLR,
  title={Mouse liver repopulation with hepatocytes generated from human
fibroblasts},
  author={Saiyong Zhu and Milad Rezvani and Jack Harbell and Aras N Mattis and Alan R Wolfe and Leslie Z Benet and Holger Willenbring and Sheng Ding},
  booktitle={Nature},
  year={2014}
}
Human induced pluripotent stem cells (iPSCs) have the capability of revolutionizing research and therapy of liver diseases by providing a source of hepatocytes for autologous cell therapy and disease modelling. However, despite progress in advancing the differentiation of iPSCs into hepatocytes (iPSC-Heps) in vitro, cells that replicate the ability of human primary adult hepatocytes (aHeps) to proliferate extensively in vivo have not been reported. This deficiency has hampered efforts to… CONTINUE READING
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