Mouse liver glutathione S-transferase mediated metabolism of methylene chloride to a mutagen in the CHO/HPRT assay.

@article{Graves1996MouseLG,
  title={Mouse liver glutathione S-transferase mediated metabolism of methylene chloride to a mutagen in the CHO/HPRT assay.},
  author={Rory Graves and Trevor Green},
  journal={Mutation research},
  year={1996},
  volume={367 3},
  pages={143-50}
}
Although methylene chloride (MC) is readily detectable as a bacterial mutagen, published studies in mammalian cells have been inconclusive. We have previously shown (Graves et al., 1995) that glutathione S-transferase (GST)-mediated metabolism of MC by mouse liver cytosol (S100 fraction) causes DNA single-strand (ss) breaks in CHO cells. In this study, MC… CONTINUE READING