Mouse lacking NAD+-linked glycerol phosphate dehydrogenase has normal pancreatic beta cell function but abnormal metabolite pattern in skeletal muscle.

@article{MacDonald2000MouseLN,
  title={Mouse lacking NAD+-linked glycerol phosphate dehydrogenase has normal pancreatic beta cell function but abnormal metabolite pattern in skeletal muscle.},
  author={Michael J. MacDonald and Linda K. Marshall},
  journal={Archives of biochemistry and biophysics},
  year={2000},
  volume={384 1},
  pages={143-53}
}
We surveyed the BALB/cHeA mouse, which lacks cytosolic glycerol phosphate dehydrogenase an enzyme that catalyzes a reaction in the glycerol phosphate shuttle. The other enzyme of this shuttle, mitochondrial glycerol phosphate dehydrogenase, is abundant in skeletal muscle and pancreatic islets suggesting that the shuttle's activity is high in these tissues. Levels of glycerol phosphate (low) and dihydroxyacetone phosphate (high) were very abnormal in nonislet tissue, especially in skeletal… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
The lactate / pyruvate ratio in muscle was low signifying a low cytosolic NAD / NADH ratio .
The lactate / pyruvate ratio in muscle was low signifying a low cytosolic NAD / NADH ratio .
The lactate / pyruvate ratio in muscle was low signifying a low cytosolic NAD / NADH ratio .
The lactate / pyruvate ratio in muscle was low signifying a low cytosolic NAD / NADH ratio .
The lactate / pyruvate ratio in muscle was low signifying a low cytosolic NAD / NADH ratio .
All Topics