Mouse keratin 4 is necessary for internal epithelial integrity.

  title={Mouse keratin 4 is necessary for internal epithelial integrity.},
  author={Seth L Ness and Winfried Edelmann and Timothy D Jenkins and Wolfgang B Liedtke and Anil K Rustgi and Raju Kucherlapati},
  journal={The Journal of biological chemistry},
  volume={273 37},
Keratins are intermediate filaments of epithelial cells. Mutations in keratin genes expressed in skin lead to human disorders, including epidermolysis bullosa simplex and epidermolytic hyperkeratosis. We examined the role of keratin 4 (K4) in maintaining the integrity of internal epithelial linings by using gene targeting to generate mice containing a null mutation in the epithelial K4 gene. Homozygous mice that do not express K4 develop a spectrum of phenotypes that affect several organs which… CONTINUE READING


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