Mouse hepatoblastomas: a histologic, ultrastructural, and immunohistochemical study.

@article{Nonoyama1988MouseHA,
  title={Mouse hepatoblastomas: a histologic, ultrastructural, and immunohistochemical study.},
  author={Takashi Nonoyama and Floyd R. Fullerton and Gayle Reznik and Thomas J. Bucci and Jerrold M Ward},
  journal={Veterinary pathology},
  year={1988},
  volume={25 4},
  pages={
          286-96
        }
}
Hepatoblastomas from B6C3F1 and BALB/c mice were examined by light and electron microscopy and by immunohistochemical reactions for alpha-fetoprotein, keratin, and vimentin. Tumors occurred in one group of a chronic bioassay for the interaction of diet, genetic strain, and the carcinogen, 2-acetylaminofluorene. Tumors had several populations (including epithelial and mesenchymal cells) in various stages of differentiation. Neoplastic epithelial cells had features of embryonal hepatocytes, such… CONTINUE READING
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