Mouse hepatitis virus strain A59 and blocking antireceptor monoclonal antibody bind to the N-terminal domain of cellular receptor.

@article{Dveksler1993MouseHV,
  title={Mouse hepatitis virus strain A59 and blocking antireceptor monoclonal antibody bind to the N-terminal domain of cellular receptor.},
  author={Gabriela S. Dveksler and Michael N. Pensiero and Carl W. Dieffenbach and Christine B. Cardellichio and Antonia Basile and P E Elia and Kathryn V. Holmes},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 5},
  pages={
          1716-20
        }
}
Mouse hepatitis virus (MHV) strain A59 uses as cellular receptors members of the carcinoembryonic antigen family in the immunoglobulin superfamily. Recombinant receptor proteins with deletions of whole or partial immunoglobulin domains were used to identify the regions of receptor glycoprotein recognized by virus and by antireceptor monoclonal antibody CC1, which blocks infection of murine cells. Monoclonal antibody CC1 and MHV-A59 virions bound only to recombinant proteins containing the… CONTINUE READING
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