Mouse hepatitis virus S in weanling Swiss mice following intranasal inoculation.

@article{Barthold1983MouseHV,
  title={Mouse hepatitis virus S in weanling Swiss mice following intranasal inoculation.},
  author={Stephen W. Barthold and Abigail L. Smith},
  journal={Laboratory animal science},
  year={1983},
  volume={33 4},
  pages={355-60}
}
Three-week-old outbred mice were inoculated intranasally with a mildly pathogenic strain of mouse hepatitis virus (MHV-S). Tissues were analyzed for distribution of infectious virus, lesions, and viral antigen at intervals up to 49 days after inoculation. Sera were tested for neutralizing antibody to MHV-S. Within the first week of infection, virus was isolated from lung and brain of most mice and liver of one mouse, but not from blood, spleen, or intestine. Microscopic lesions consisted of… CONTINUE READING

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