Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype.

@article{Mantel2012MouseHC,
  title={Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype.},
  author={Charlie R. Mantel and Steven V Messina-Graham and Akira Moh and Scott Cooper and Giao Hangoc and Xin-yuan Fu and Hal E. Broxmeyer},
  journal={Blood},
  year={2012},
  volume={120 13},
  pages={2589-99}
}
Nuclear transcription factor Stat3 is important for proper regulation of hematopoietic stem cell (HSC) and hematopoietic progenitor cell (HPC) proliferation, survival, and cytokine signaling responses. A new, noncanonical role for Stat3 in mitochondrial function has been discovered recently. However, there is little information on the role(s) of mitochondrial Stat3 in HSC/HPC function, especially potential effects of Stat3/mitochondrial dysregulation in human diseases. We investigated… CONTINUE READING