Mouse grooming microstructure is a reliable anxiety marker bidirectionally sensitive to GABAergic drugs.

@article{Kalueff2005MouseGM,
  title={Mouse grooming microstructure is a reliable anxiety marker bidirectionally sensitive to GABAergic drugs.},
  author={Allan Kalueff and Pentti Tuohimaa},
  journal={European journal of pharmacology},
  year={2005},
  volume={508 1-3},
  pages={147-53}
}
Grooming is an important part of rodent behavioural repertoire, representing a complex hierarchically ordered cephalo-caudal sequence of patterns sensitive to stress and various drugs. Gamma-aminobutyric acid (GABA) is involved in the regulation of both anxiety and grooming behaviours. This study investigated the predictive validity of grooming behavioural microstructure as a marker of anxiety, by examining the effects of two GABAergic reference compounds, anxiolytic diazepam (0.1 and 0.5 mg/kg… CONTINUE READING