Mouse glucose-6-phosphate isomerase and neuroleukin have identical 3′ sequences

  title={Mouse glucose-6-phosphate isomerase and neuroleukin have identical 3′ sequences},
  author={Pelin Faik and James I. H. Walker and A A Redmill and Michael J. Morgan},
Neuroleukin is a neurotrophic factor of relative molecular mass (Mr) 56,000 (56K) found in skeletal muscle, brain, heart and kidneys which supports the survival of embryonic spinal neurones, skeletal motor neurones and sensory neurons1. Neuroleukin is also a lymphokine product of lectin-stimulated T cells and induces immunoglobulin secretion by cultured human peripheral blood mononuclear cells2>. Mouse neuroleukin has been cloned, the complete nucleotide sequence has been determined1 and its… 
Cloning of a Glucose Phosphate Isomerase/Neuroleukin-Like Sperm Antigen Involved in Sperm Agglutination1
It is demonstrated that mAb A36 cognate sperm surface antigen, encoded by SA-36 cDNA, is a GPI/NLK-like protein involved in sperm agglutination.
Expression of the AMF/neuroleukin receptor in developing and adult brain cerebellum
Data indicate that regulation of the neurotrophic function of neuroleukin might be regulated spatially and temporally by expression of its receptor, AMF‐R, in developing and adult cerebellum.
Tumor cell autocrine motility factor is the neuroleukin/phosphohexose isomerase polypeptide.
The results demonstrate that AMF is the previously cloned cytokine and enzyme designated as neuroleukin, and phosphohexose isomerase (PHI), which has been independently implicated in cell motility, and to be a cancer progression marker.
The crystal structure of a multifunctional protein: phosphoglucose isomerase/autocrine motility factor/neuroleukin.
The complete crystal structure of PGI from Bacillus stearothermophilus is presented and it is shown that PGI has cell-motility-stimulating activity on mouse colon cancer cells similar to that of endogenous autocrine motility factor (AMF).
Neuronal Survival Factor from Bovine Brain Is Identical to Neuron‐Specific Enolase
Highly purified NSE supported the survival of cultured neurons in a dose‐dependent manner, and the neurotrophic effect was inhibited by monoclonal antibody to the NSE.
Purification and characterization of phosphohexose isomerase from human gastrointestinal carcinoma and its potential relationship to neuroleukin.
The results obtained support the hypothesis that three PHI variants derived from human gastrointestinal tumor tissue are due to a specific intracellular cleavage of the enzyme in the malignant cells.
Structure of native phosphoglucose isomerase from rabbit: conformational changes associated with catalytic function.
  • C. Davies, H. Muirhead
  • Chemistry, Biology
    Acta crystallographica. Section D, Biological crystallography
  • 2003
The crystal structure of PGI in the native form from rabbit muscle has been solved at a resolution of 2.5 A by a combination of multiple isomorphous replacement and multi-crystal averaging techniques and a number of conformational changes that may be associated with catalytic function.
The differentiation and maturation mediator for human myeloid leukemia cells shares homology with neuroleukin or phosphoglucose isomerase.
Abnormally elevated PGI enzyme activities were detected in the plasma of acute myelogenous leukemia patients, whether they represent an excess of the differentiation regulator in patients and are important in leukemogenesis remain to be investigated.
Glucose-6-phosphate isomerase deficiency.
This chapter reviews the clinical pattern of the condition; biochemical and molecular studies; structure-function relationships; the molecular basis of neurological dysfunctions sometimes associated with GPI deficiency; and the correlation between the severity of the anaemia and the molecular defect.
Glucosephosphate isomerase from Trypanosoma brucei. Cloning and characterization of the gene and analysis of the enzyme.
A detailed study of the glucose-6-phosphate isomerase of Trypanosoma brucei, involving a determination of its kinetic properties and the cloning and sequence analysis of its gene, revealed no major differences.


The neurotrophic factor neuroleukin is 90% homologous with phosphohexose isomerase
Molecular clones of NLK have been expressed in monkey COS cells and the product was shown to have the same biological and biochemical properties as the extracted protein, and its amino-acid sequence is 90% homologous to the sequence of mouse neuroleukin.
Molecular cloning and expression of neuroleukin, a neurotrophic factor for spinal and sensory neurons.
A novel 56,000-dalton growth factor found in mouse salivary gland was purified, molecularly cloned, and expressed in monkey COS cells, and the factor was named neuroleukin, a neurotrophic factor and also a lymphokine product of lectin-stimulated T cells.
Glucose-6-phosphate isomerase.
A tentative fit of two of the peptides to the electron density map has been made and it seems possible that glucose-6-phosphate isomerase, triose phosphate isomersase and pyruvate kinase all contain a histidine and a glutamate residue at the active site.
Neuroleukin: a lymphokine product of lectin-stimulated T cells.
Neuroleukin is a lymphokine product of lectin-stimulated T cells that induces immunoglobulin secretion by cultured human peripheral blood mononuclear cells that is both monocyte- and T-cell-dependent.
Functional interaction and partial homology between human immunodeficiency virus and neuroleukin.
The inhibition by HIV-1 of neuron growth in the presence of NLK was found to be due to the gp120 envelope glycoprotein, and regions of sequence homology between gp120 and NLK may account for this inhibitory property of gp120.
Inhibition of terminal axonal sprouting by serum from patients with amyotrophic lateral sclerosis.
An antibody in the serum of patients with amyotrophic lateral sclerosis is detected that inhibits sprouting of neurons and subsequent reinnervation of skeletal muscle, and may provide reagents for studies of the trophic communications between muscle and motor neurons.
DNA sequencing with chain-terminating inhibitors.
A new method for determining nucleotide sequences in DNA is described, which makes use of the 2',3'-dideoxy and arabinon nucleoside analogues of the normal deoxynucleoside triphosphates, which act as specific chain-terminating inhibitors of DNA polymerase.
Pathogenesis of infection with human immunodeficiency virus.
The acquired immunodeficiency syndrome (AIDS) was first described in 1981, but it has since reached epidemic proportions, with over 38,000 cases reported in the United States alone and a three-year...