Mouse flt-1 promoter directs endothelial-specific expression in the embyroid body model of embryogenesis.

@article{Quinn2000MouseFP,
  title={Mouse flt-1 promoter directs endothelial-specific expression in the embyroid body model of embryogenesis.},
  author={Gary Quinn and Takahiro Ochiya and Masaki Terada and Teruhiko Yoshida},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={276 3},
  pages={1089-99}
}
The endothelial-specific receptor tyrosine kinase flt-1 (VEGFR-1) is expressed early on during endothelial lineage commitment both in vivo and in vitro. However, the exact function of flt-1 in vascular development still remains unclear. Here we report that a 2.2-kb fragment 5' of the mouse flt-1 gene becomes transcriptionally active during endothelial cell… CONTINUE READING