Mouse fibroblasts lacking RB1 function form spheres and undergo reprogramming to a cancer stem cell phenotype.

@article{Liu2009MouseFL,
  title={Mouse fibroblasts lacking RB1 function form spheres and undergo reprogramming to a cancer stem cell phenotype.},
  author={Yongqing Liu and Brian F. Clem and Ewa K. Zuba-Surma and Shahenda El-Naggar and Sucheta Telang and Alfred Bennett Jenson and Yali Wang and Hui Shao and Mariusz Z Ratajczak and Jason D Chesney and Douglas C. Dean},
  journal={Cell stem cell},
  year={2009},
  volume={4 4},
  pages={336-47}
}
Activation of the RB1 pathway triggers the cell-cycle arrest that mediates cell-cell contact inhibition. Accordingly, mutation of all three RB1 family members leads to loss of contact inhibition and outgrowth of fibroblasts into spheres where cell-cell contacts predominate. We present evidence that such outgrowth triggers reprogramming to generate cells with properties of cancer stem cells. Fibroblasts with only a single RB1 mutation remain contact inhibited; however, if this contact inhibition… CONTINUE READING
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