Mouse erythropoietic stem cell lines function normally 100 months: loss related to number of transplantations.

@article{Harrison1979MouseES,
  title={Mouse erythropoietic stem cell lines function normally 100 months: loss related to number of transplantations.},
  author={David E. F. Harrison},
  journal={Mechanisms of ageing and development},
  year={1979},
  volume={9 5-6},
  pages={427-33}
}
Marrow stem cell lines from old and young donors in parallel experiments were transplanted into genetically anemic W/WV recipients. These recipients were populated and their anemias were cured by stem cell lines from WCB6F1 or C57BL/6 dorons that had been repeatedly transplanted up to five times at annual intervals into successive W/WV recipients. Old marrow cell lines produced erythrocytes normally for as long as 2600 to 3000 days. However, after three to four serial transplantations many stem… CONTINUE READING