Mouse embryonic stem cell-derived embryoid bodies generate progenitors that integrate long term into renal proximal tubules in vivo.

@article{Vigneau2007MouseES,
  title={Mouse embryonic stem cell-derived embryoid bodies generate progenitors that integrate long term into renal proximal tubules in vivo.},
  author={C{\'e}cile Vigneau and Katalin Polgar and Gary E. Striker and Justine Elliott and Deborah P. Hyink and Olmar Baller Weber and H. Fehling and Guillermo A. Keller and Christopher R. Burrow and Patricia Wilson},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2007},
  volume={18 6},
  pages={
          1709-20
        }
}
The metanephric kidney is a mesodermal organ that develops as a result of reciprocal interactions between the ureteric bud and the blastema. The generation of embryonic stem (ES) cell-derived progenitors offers potential for regenerative therapies but is often limited by development of tumor formation. Because brachyury (T) denotes mesoderm specification, a mouse ES cell line with green fluorescence protein (GFP) knocked into the functional T locus as well as lacZ in the ROSA26 locus (LacZ/T… CONTINUE READING
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