Mouse complement regulatory protein Crry/p65 uses the specific mechanisms of both human decay-accelerating factor and membrane cofactor protein

@article{Kim1995MouseCR,
  title={Mouse complement regulatory protein Crry/p65 uses the specific mechanisms of both human decay-accelerating factor and membrane cofactor protein},
  author={Youn Uck Kim and Taroh Kinoshita and H{\'e}ctor R Molina and Dennis E. Hourcade and Tsukasa Seya and Lynn M. Wagner and V. Michael Holers},
  journal={The Journal of Experimental Medicine},
  year={1995},
  volume={181},
  pages={151 - 159}
}
Normal host cells are protected from the destructive action of complement by cell surface complement regulatory proteins. In humans, decay-accelerating factor (DAF) and membrane cofactor protein (MCP) play such a biologic role by inhibiting C3 and C5 convertases. DAF and MCP accomplish this task by specific mechanisms designated decay-accelerating activity and factor I cofactor activity, respectively. In other species, including mice, structural and/or functional homologues of these proteins… CONTINUE READING