Mouse cmos oncogene activation is prevented by upstream sequences ( transcriptional regulation / DNA transfection / cell transformation )

@inproceedings{WoodMouseCO,
  title={Mouse cmos oncogene activation is prevented by upstream sequences ( transcriptional regulation / DNA transfection / cell transformation )},
  author={Thomas G. Wood and M. L. and MCGEADYt and B. M. Baroudy and Donald G. Blair and G. F. VANDE WOUDEt}
}
Although the molecularly cloned mouse cmos oncogene locus can be efficiently activated by insertion of a retroviral long terminal repeat (LTR) 5' to its coding region, only low-frequency transformation occurs with the LTR element inserted 3' to this region. Analysis of several of the latter transformed cell lines suggested that loss of 2 kilobases (kb) of normal mouse DNA sequences preceding c-mos was required for oncogene activation. The determination of the transforming potential of deletion… CONTINUE READING

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