Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate.

@article{Strisovsky2003MouseBS,
  title={Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate.},
  author={Kvido Strisovsky and Jana Jir{\'a}skov{\'a} and Cyril Barinka and Pavel Majer and Camilo Rojas and Barbara S Slusher and Jan Konvalinka},
  journal={FEBS letters},
  year={2003},
  volume={535 1-3},
  pages={44-8}
}
D-Serine was previously identified in mammalian brain and was shown to be a co-agonist at the 'glycine' site of the N-methyl-D-aspartate (NMDA)-type receptors. Racemization of serine is catalyzed by serine racemase, a pyridoxal 5'-phosphate-dependent enzyme expressed mainly in brain and liver. NMDA receptor overactivation has been implicated in a number of pathological conditions and inhibitors of serine racemase are thus potentially interesting targets for therapy. We expressed recombinant… CONTINUE READING