Mouse brain distribution of a carbon-11 labeled vesamicol derivative: presynaptic marker of cholinergic neurons.

@article{Kilbourn1990MouseBD,
  title={Mouse brain distribution of a carbon-11 labeled vesamicol derivative: presynaptic marker of cholinergic neurons.},
  author={Michael R. Kilbourn and Yong Woo Jung and M S Haka and David L. Gildersleeve and David E. Kuhl and Donald M. Wieland},
  journal={Life sciences},
  year={1990},
  volume={47 21},
  pages={
          1955-63
        }
}
The regional mouse brain distribution of a new carbon-11 labeled derivative of vesamicol, [11C]-5-(N-methylamino)benzovesamicol [( 11C]MABV) is reported. Radiotracer concentrations in vivo are in the rank order of striatum greater than cortex greater than hippocampus greater than hypothalamus greater than cerebellum, consistent with reported distributions of other presynaptic cholinergic neuronal markers. In time course studies, striatum/cerebellum and cortex/cerebellum ratios for (-)-[11C]MABV… CONTINUE READING
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