Mouse bone marrow-derived IL-3-dependent mast cells and autonomous sublines produce IL-6.

@article{Hltner1989MouseBM,
  title={Mouse bone marrow-derived IL-3-dependent mast cells and autonomous sublines produce IL-6.},
  author={Lothar H{\"u}ltner and H Sz{\"o}ts and Monika Welle and Jacques L. van Snick and Jochen Moeller and Peter D{\"o}rmer},
  journal={Immunology},
  year={1989},
  volume={67 3},
  pages={408-13}
}
This study deals with the question of whether mouse bone marrow-derived mast cells are able to produce interleukin-6 (IL-6) in vitro. For this purpose, a panel of primary mast cell clones from limiting-dilution microcultures, of permanent IL-3-dependent mast cell lines and autonomous malignant sublines, was screened. All of these lines were found to produce growth factor activity for IL-6-dependent mouse hybridoma cells (7TD1), which could be completely neutralized by the monoclonal anti-IL-6… CONTINUE READING
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